Clinical Uses of 2,3-dimercaptopropanol (bal). Vii. the Treatment of Arsenical Dermatitis with Preparations of Bal.

نویسندگان

  • W T Longcope
  • J A Luetscher
  • M M Wintrobe
  • V Jäger
چکیده

The development of 2,3-dimercaptopropanol (British Anti-Lewisite, BAL) by Peters, Stocken, and Thompson (1) has made available a potent antidote for arsenical poisoning. Study of the chemical combination of arsenic with sensitive enzymes and cells indicated that the arsenic could, under certain circumstances, be removed from the cells, and that enzymes could be reactivated by the action of BAL (1, 2). BAL administered to animals exerted both protective and therapeutic effects against local and systemic injury by toxic arsenicals (1, 2). These observations strongly suggested that BAL might be useful in arsenical poisoning in man, and cautious trials were initiated in this hospital at the end of 1942.

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منابع مشابه

Clinical Uses of 2,3-dimercaptopropanol (bal). X. the Treatment of Acute Systemic Mercury Poisoning in Experimental Animals with Bal, Thiosorbitol and Bal Glucoside.

Although chemical agents were not employed as offensive weapons during the past war, nevertheless it was imperative to pursue vigorously investigations on the treatment of chemical warfare casualties. Inasmuch as a number of chemical warfare agents contain arsenic, attention was focused on the synthesis of compounds capable of antagonizing the local and systemic effects of arsenical vesicants. ...

متن کامل

Clinical Uses of 2,3-dimercaptopropanol (bal). X. the Treatment of Acute Systemic Mercury Poisoning

Although chemical agents were not employed as offensive weapons during the past war, nevertheless it was imperative to pursue vigorously investigations on the treatment of chemical warfare casualties. Inasmuch as a number of chemical warfare agents contain arsenic, attention was focused on the synthesis of compounds capable of antagonizing the local and systemic effects of arsenical vesicants. ...

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 25 4  شماره 

صفحات  -

تاریخ انتشار 1946